| Date | Time | Home | Away | Matchday | TV | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
D | 2022-03-06 | 12:00 | Resistencia SC |  | 1-1 |  | Guaireña FC | D2 | ||||
L | 2022-03-12 | 20:00 | Guaireña FC | | 0-3 |  | Olimpia | D3 | ||||
L | 2022-03-22 | 19:30 | Guaireña FC | | 4-5 |  | General Caballero JLM | D5 | ||||
L | 2022-03-25 | 13:00 | Sol de América |  | 2-1 | | Guaireña FC | D6 | ||||
L | 2022-04-01 | 15:00 | Cerro Porteño |  | 4-1 | | Guaireña FC | D4 | ||||
W | 2022-04-23 | 20:00 | Guaireña FC | | 2-1 |  | Tacuary | D7 | ||||
L | 2022-05-03 | 20:00 | Guaireña FC | | 1-2 |  | Guaraní | D9 | ||||
D | 2022-05-09 | 15:00 | Nacional/Humaitá |  | 3-3 | | Guaireña FC | D10 | ||||
W | 2022-05-15 | 14:30 | Guaireña FC | | 3-1 |  | River Plate | D11 | ||||
L | 2022-05-29 | 20:00 | Libertad |  | 6-0 | | Guaireña FC | D13 | ||||
