| 2022/09/20 | Dulwich Hamlet |  | 5-2 |  | Athletic Newham | ||||
| 2022/09/27 | Corinthian-Casuals |  | 0-1 |  | Brentford B | ||||
| Wingate & Finchley |  | 4-1 |  | Clapton FC | |||||
| 2022/10/04 | Harrow Borough |  | 0-2 |  | Cockfosters | ||||
| 2022/10/05 | New Salamis |  | 2-2 |  | Woodford Town | ||||
| 2022/10/12 | Phoenix Sports |  | 0-6 |  | Charlton Athletic U21 | ||||
| 2022/10/18 | Glebe FC |  | 1-0 |  | Fisher FC | ||||
| Dartford |  | 1-0 |  | Tooting & Mitcham Utd | |||||
| Cray Valley PM |  | 0-1 |  | Welling United | |||||
| 2022/10/19 | Balham |  | 0-2 |  | AFC Wimbledon U21 | ||||
| 2022/10/25 | Barking FC |  | 2-2 |  | AFC Croydon Athletic | ||||
| 2022/11/01 | Hendon |  | 4-2 |  | Erith Town FC | ||||
| Redbridge FC |  | 2-5 |  | Erith & Belvedere | |||||
| 2022/11/02 | Cray Wanderers |  | 1-0 |  | Leyton Orient U21 | ||||
| 2022/11/19 | Metropolitan Police |  | 4-0 |  | Hilltop FC |
